MicroCap Single-Use Depth Filter Capsules

MicroCap Single-Use Capsules

MicroCap single-use depth filter capsules are available in 6 different sizes (1 in., 2.5 in., 5 in., 10 in., 20 in. and 30 in. in height) ranging in effective filter area from 23 cm² to 2880 cm² with single-layer media (23 cm² to 1500 cm² with double-layer media). This enables processing without the necessity of pooling multiple batches of material to efficiently utilize the available single-use capsule.

MC1 Single-Use Depth Filter Capsule

The MC1 single-use depth filter capsule*is designed to suit your testing needs as a screening tool for depth filter media selection. The MC1 filter capsule provides optimal throughput and predictive, scalable results from small batch sizes ranging from approximately 0.5 liters to 3 liters.
Positioned for use during laboratory development and optimization of scale-up and scale-down studies, MC1 depth filter capsules, with 23 cm² of effective filter area (EFA), are effective tools for quickly determining the correct depth filter media to suit your processing needs. With the same filter media, flow paths and design as the larger single-use capsules in this series, the MC1 single-use capsule allows for simplified process development studies.

*The MC1 is also available in the MicroCap Laboratory Cabinet.

MC2 & MC5 Single-Use Depth Filter Capsule

The MC2 and MC5 single-use depth filter capsules are intended for use in processes batch sizes typical of early stage laboratory to process development ranging from approximately 3 to 15 liters. Available with a large variety of depth filter media options and optional inlet/outlet configurations, MicroCap single-use capsules provide simple, reliable capsule performance suited to your process needs.

Specs. MC1 MC2 MC5
Enclosure Polypropylene Polypropylene Polypropylene
Connections Hose Barb Hose Barb or 1/2 in. Sanitary Clamp Hose Barb or 1/2 in. Sanitary Clamp
Drain & Vent Seals N/A Silicone Silicone
Vent Luer Loc Vent Valve Vent Valve
Sinlge-Layer Filter Area 23 cm2 170 cm2 330 cm2
Double-Layer Filter Area 23 cm2 80 cm2 170 cm2
Operating Pressure Limit 2.5 barg (36 psig) @ 22 ºC 5.5 barg (80 psig) @ 22 ºC 5.5 barg (80 psig) @ 22 ºC
Approx. Batch Size 0.05 – 3 l 3 – 10 l 5 – 15 l
*All dimensions are for reference only.

MC10, MC20 & MC30 Single-Use Depth Filter Capsule

Intended for larger volume processing (10 to 50 or more liters), the MC10, MC20, and MC30 MicroCap capsules share the same internal structure, flow path, and robust design as the smaller capsules in the MicroCap line. These T-style capsules are easily manifolded to seamlessly integrate additional filter area or establish a fully encapsulated filter train. With effective filter areas of 960 cm., 1920 cm. and 2880 cm. in single-layer format (500 cm., 1000 cm. and 1500 cm. in double‑layer format) the MC10, MC20 and MC30 MicroCap capsules are ideally sized for larger process development though production scale needs.

Specs. MC10 MC20 MC30
Enclosure Polypropylene Polypropylene Polypropylene
Connections 1.5 in. Sanitary Clamp 1.5 in. Sanitary Clamp 1.5 in. Sanitary Clamp
Drain & Vent Seals Silicone Silicone Silicone
Vent 0.25 in Bleed Valve 0.25 in Bleed Valve 0.25 in Bleed Valve
Sinlge-Layer Filter Area 960 cm2 1920 cm2 2880 cm2
Double-Layer Filter Area 500 cm2 1000 cm2 1500 cm2
Operating Pressure Limit 5.5 barg (80 psig) @ 22 ºC 5.5 barg (80 psig) @ 22 ºC 5.5 barg (80 psig) @ 22 ºC
Approx. Batch Size 10 – 20 l 15 – 30 l 25 – 50 l
*All dimensions are for reference only.
AdvantagesProcessesApplicationsDownloads
  • Lowest Extractable Levels
  • Zero Cleaning
  • Increased Particle Retention
  • Completely Disposable
  • Extended Throughput
  • Up to 2880 cm2 of filtration area
  • Autoclaveable
  • Mammalian cell cultures
  • Bacteria, yeast, and insect cell lysates
  • Vaccines
  • Blood plasma proteins and serum
  • Media
  • Primary separations/prefiltration
  • Secondary clarification
  • Cell culture harvest
  • Cell culture clarification
  • DNA reduction
  • Endotoxin reduction
  • Host Cell Protein (HCP) reduction
  • Protein aggregate removal
  • Decolorization