Complex of Filtration Mediums
PXL media is a complex of filtration mediums that enable significantly improved throughput and superior contaminant retention in high solids loading processes. Designed specifically for applications as an initial prefilter or clarification stage filter, PXL media is ideal for protecting price and contaminant sensitive process steps further downstream.
Comprised of ErtelAlsop’s XL Series depth filter media, PXL media has the filtration benefits and extremely low extractables content that comes from highly purified diatomaceous earth (DE). Couple this with our proprietary P200 web complex, and the PXL media is unparalleled by other traditional cellulosic based depth filter media in gross contaminant loading capabilities.
PXL media is designed to be the upstream bioprocessing filtration workhorse in those soft particulate, high cell count/low viability applications that readily foul the surfaces of other depth filter media. Filtering these solutions with regular depth media results in a rapid decline and termination of flow rate and throughput.
PXL media optimizes the filtration of soft particulate solutions over time by:
- Reduced fouling rate of the filter
- Reduced rate of operating pressure buildup
- Increased flowrate and throughput per setup
The effect of process improvements can be felt through cost savings in time and materials. Nowhere is that more evident than with the results seen with improved throughput that comes with the use of PXL media. With typical throughput improvements averaging 3 to 4x, the time involved in initial solids removal can be dramatically reduced and the amount of filtration area necessary can be significantly lowered all amounting to reduction in processing step costs.
With such dramatic improvements in solids removal through the use of ErtelAlsop’s new PXL filter media, the use of other more expensive and capital equipment intensive techniques become less attractive. For example
- Centrifuges pose problems due to their lack of flexibility in sizing and their expense in ever larger systems as process scales increase.
- Chemical flocculants, while promising, lack federal approval and longer term effects on product stability, efficacy and patient exposure have yet to be fully studied.
- Filter presses, still widely used in some markets, lack closed processing, are labor and capital intensive.
Available Product Range/Scalable Formats
ErtelAlsop has made PXL media available in six different sizes of scalable, single-use disposable MicroCap capsules as well as 12 inch and 16 inch diameter lenticular filters for use in housings. Effective filter areas (EFA) range from as little as 23cm² to as much as 3.8 m² per 16 inch Pak lenticular cartridge.
ErtelAlsop’s 12 inch diameter and 16 inch diameter lenticular filters are available in a number of different formats containing either flat gasket or locking double o-ring end fittings.
- High purity
- USP Class VI tested
- Fully lot traceable
- Low endotoxin content
- Supported through Validation Guide
Some of the applications for PXL media are:
- Bulk Fermentation Cell and Debris Removal
- Mamalian Cell Culture Clarification
- Most other viscous bioprocess solutions with a high concentration of soft particulate
ErtelAlsop also offers a Validation Guide to assist in the validation of its filter pads in your process. The Validation Guide contains information regarding raw materials, extractables, and general information about the product. The combination of ErtelAlsop “P” grade filter pads and ErtelAlsop’s BioClean® plate and frame filter press design, can help to simplify your depth filtration validation now more than ever.